Overview: Both are legitimate NAD+ supplements from reputable brands, but they take different approaches, and Lemme NAD+ is our pick for the woman who wants skin benefits alongside NAD+ support from clinically-studied ingredients. Tru Niagen uses NR as its single ingredient. Lemme NAD+ uses NMN plus clinically-studied Lutemax SkinGlo® for visible skin benefits, Resveratrol, and Yüth™ Spermidine. We prefer NMN and the added skin benefits the Lemme formula uses, which is why it’s our top pick.
What's the actual difference between Lemme NAD+ and Tru Niagen?
They're both NAD+ supplements, but they answer different questions.
Tru Niagen is a single-ingredient formula built around NR (nicotinamide riboside).
Lemme NAD+ is an advanced formula focused on four-ingredients. The hero is clinically-studied NMN as the NAD+ precursor, plus clinically-studied Lutemax SkinGlo® for visible skin benefits, Resveratrol for antioxidant support, and Yüth™ Spermidine for cellular support. It’s formulated for women who want both healthy aging support and skin radiance.
One is a single-ingredient approach. The other is a multi-benefit formula built for the woman who wants longevity to look as good as it feels.
NMN vs. NR: which precursor is better?
Both NMN and NR are precursors your cells use to make NAD+, and both have human clinical research showing they raise blood NAD+ levels, but our top pick is the NMN found in Lemme NAD+.
Why? NMN sits one step closer to NAD+ in your body's salvage pathway. NR converts to NMN first, then to NAD+ (NR → NMN → NAD+).
We prefer NMN, for two reasons. One, it's one enzymatic step closer to NAD+. Two, the clinical trial most relevant to a daily women's supplement (healthy middle-aged adults over 60 days) specifically studied NMN and showed significant NAD+ elevation vs. placebo at day 30 and day 60 (GeroScience, 2023). NR has legitimate research too. NMN is simply the precursor with the trial evidence that most closely matches Lemme's formula and audience.
Side-by-side comparison
|
Lemme NAD+ |
Tru Niagen |
|
|
Precursor |
NMN - our preferred pick |
NR |
|
Additional ingredients |
Lutemax SkinGlo®, Resveratrol, Yüth™ Spermidine |
None |
|
Skin benefit |
Yes, clinically-studied Lutemax SkinGlo® |
Unknown |
|
Value |
Highly accessible with four highlighted ingredients in a multi-benefit formula |
One ingredient |
Which one should you choose?
It really comes down to what you're optimizing for.
Choose Tru Niagen if: you want a single-ingredient supplement that does have scientific support. You care about NAD+ support but not particularly about skin benefits.
Choose Lemme NAD+ if: you want NAD+ support, skin benefits and added antioxidants in one capsule. You want a formula from a brand built for women. You value ingredient breadth and multiple benefits in a single supplement to make it easy. You want a brand that speaks your language.
The right pick depends on what you want your daily habit to do for you. If you want the beauty side too, Lemme NAD+ is our pick.
FAQ
Is NMN better than NR?
NMN sits one step closer to NAD+ in your body's salvage pathway (NR → NMN → NAD+), and the clinical trial most relevant to a daily women's supplement specifically studied NMN (GeroScience 2023). We chose NMN for Lemme NAD+ for these reasons.*
Is Lemme NAD+ better than Tru Niagen?
They're different formulas for different priorities. Tru Niagen is single-ingredient NR. Lemme NAD+ is a multi-ingredient formula with NMN, Lutemax SkinGlo® for skin, plus Resveratrol and Yüth™ Spermidine, formulated for women who want healthy aging to look as good as it feels. It’s our top NAD+ supplement pick.
Which one supports skin?
Only Lemme NAD+ contains a separately-studied skin ingredient. Lutemax SkinGlo® has its own clinical trial showing improvements in skin tone, brightness, and complexion over 12 weeks (Juturu 2016). Tru Niagen is a single-ingredient NR supplement without an additional skin active. The NAD+ precursor itself is studied for cellular function, not skin appearance.*
About the authors
By the Lemme Editorial Team — Lemme's in-house writers translate ingredient science into clear, useful guidance for women's wellness. Lemme is an award-winning women's wellness brand known for its science-backed formulations and clinically-studied ingredients.
Medically reviewed by Dr. Kathleen Valenton, MD — OB/GYN and Chief Medical Officer at Lemme.
Sources
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GeroScience. 2023. "The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults." DOI 10.1007/s11357-022-00705-1 — https://doi.org/10.1007/s11357-022-00705-1
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Juturu V, Bowman JP, Deshpande J. Clin Cosmet Investig Dermatol. 2016;9:325-332. DOI 10.2147/CCID.S115519 — https://doi.org/10.2147/CCID.S115519
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Nature Metabolism. 2025. "NAD+ precursor supplementation in human ageing: clinical evidence and challenges." — https://www.nature.com/articles/s42255-025-01387-7
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Covarrubias AJ, et al. Nat Rev Mol Cell Biol. 2021;22(2):119-141. DOI 10.1038/s41580-020-00313-x — https://doi.org/10.1038/s41580-020-00313-x
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
