Dr. Kathleen Valenton    MD, OBGYN Written by Dr. Kathleen ValentonMD, OBGYN

Key takeaways

  • Lemme Burn Gummies support healthy fat loss and body composition,*† featuring Morosil® — a patented red orange extract studied at 400mg in two peer-reviewed clinical trials.

  • Lemme Burn Capsules regulate metabolism, belly fat loss and support health weight maintenance,*† featuring Actiponin® — a patented Gynostemma pentaphyllum extract studied at 450mg in a peer-reviewed clinical trial through AMPK activation.

  • The two formulas are built around different lead actives working through complementary metabolic mechanisms.

  • Some users incorporate both into their routine for layered metabolic support, while others choose one based on format preference, lifestyle, or specific goals.

 


 

The short answer

Lemme Burn Gummies and Lemme Burn Capsules are two distinct formulations within the Lemme Burn franchise — designed around different lead actives, different mechanisms, and different goals. Lemme Burn Gummies are formulated to support fat loss and healthy body composition.*† Lemme Burn Capsules are formulated to regulate metabolism, target belly fat and support healthy weight management.*† Both work to support healthy metabolism, but they're built to do it in different ways.

Lemme Burn Gummies are anchored by Morosil®, a patented red orange extract studied in two peer-reviewed human clinical trials for its effect on lipid metabolism and body composition. The formula also includes Black Ginger Extract, Chromium Picolinate, and bioactive B vitamins.

Lemme Burn Capsules are anchored by Actiponin®, a patented Gynostemma pentaphyllum extract studied in a peer-reviewed human clinical trial at 450mg, working through AMPK activation — the body's cellular energy regulator. The formula also includes high-potency green tea extract (98% polyphenols, 50% EGCG) and bioactive B vitamins.

The two formulas are built around different lead actives — meaning they target metabolism through different scientific mechanisms.


 

Lemme Burn Gummies vs. Capsules: side-by-side


Lemme Burn Gummies

Lemme Burn Capsules

Lead active

Morosil® (red orange extract)

Actiponin® (Gynostemma pentaphyllum extract)

Lead active dose

400mg

450mg

Dose-matched to clinical research

Yes — matches both Cardile 2015 and Briskey 2022 trials

Yes — matches the Park 2014 trial

Mechanism & primary use

Lipid metabolism / body composition*

AMPK activation / weight management*

Other actives

Black Ginger Extract, Chromium Picolinate, B6, B12

Green Tea Extract (50% EGCG), B6, B12

Format

Berry-flavored gummy

Vegan capsule

Daily serving

2 gummies

2 capsules, with food

Caffeine

None

Trace amount (from green tea)

B vitamin doses

B6: 3mg / B12: 25mcg

B6: 5mg / B12: 500mcg


 


 

How Lemme Burn Gummies work

Lemme Burn Gummies are built around Morosil®, a standardized extract from the Moro variety of Sicilian blood orange. In two peer-reviewed clinical trials — a 12-week study and a 6-month replication study — participants taking 400mg of Morosil® daily showed measurable improvements in body composition markers compared to placebo, including BMI, and waist and hip circumference.


The mechanism: Morosil® is rich in anthocyanins and other bioactive compounds that research suggests influence lipid metabolism through gene-level effects (Briskey et al., 2022; Titta et al., 2010) — affecting how fat cells accumulate and how the body processes fatty acids.


The Gummies formula also includes Black Ginger Extract, Chromium Picolinate, and bioactive Vitamin B6 and B12 for complementary metabolic support.


For the complete breakdown of the science behind Lemme Burn Gummies, read our full article on whether Lemme Burn Gummies actually work.


 


 

How Lemme Burn Capsules work

Lemme Burn Capsules are built around Actiponin®, a patented, heat-processed Gynostemma pentaphyllum leaf extract. In a peer-reviewed clinical trial, participants taking 450mg of Actiponin® daily for 12 weeks showed statistically significant reductions in total abdominal fat, body fat mass, percent body fat, and BMI compared to placebo. Notably, both groups maintained comparable diet and lifestyle throughout the study — meaning the differences in outcomes are attributable to Actiponin® itself, not to lifestyle changes.

The mechanism: Actiponin® contains two unique compounds called damulin A and damulin B that have been studied for their role in activating AMPK (AMP-activated protein kinase) — an enzyme found in nearly every cell of the body that acts as the body's cellular energy regulator. When AMPK is activated, it shifts the body's metabolic priorities toward fat oxidation, reduced fat storage, and supporting cellular energy production.*

The Capsules formula also includes high-potency Green Tea Extract (98% polyphenols, 50% EGCG) — which has also been studied for its role in AMPK activation — plus bioactive Vitamin B6 and B12.

For the complete breakdown of the science behind Lemme Burn Capsules, read our full article on whether Lemme Burn Capsules actually work.


 

Two formulas, two mechanisms

The most important difference between the two products isn't format or flavor — it's the underlying scientific mechanism each one targets.

Morosil® (in the Gummies) supports lipid metabolism. Research suggests its bioactive compounds influence how the body processes fats — affecting fatty acid biosynthesis, oxidation, and how adipocytes (fat cells) accumulate lipids (Briskey et al., 2022).

Actiponin® (in the Capsules) activates AMPK. AMPK is a regulatory enzyme that functions as the master cellular energy regulator, and Actiponin®'s damulin compounds have been studied for their role in activating it — leading to increased fat oxidation and reduced fat storage at the cellular level.

These are different mechanisms. They affect different metabolic processes. And they don't depend on each other to work.

"From a metabolic-physiology standpoint, lipid metabolism and AMPK activation are genuinely distinct mechanisms — they target different aspects of how the body manages energy. That's what makes the two Lemme Burn formulations a thoughtful pair rather than two versions of the same thing." Dr. Valenton, MD, Board-Certified OB-GYN

 


 

Which one is right for you?

The right Lemme Burn product depends on your goals, your routine, and your format preference.

Lemme Burn Gummies may be a good fit if you:

  • Prefer a gummy format and don't love taking capsules

  • Want a daily wellness gummy that fits naturally alongside other Lemme gummies

  • Are caffeine-sensitive (the Gummies contain none)

  • Are primarily focused on supporting body composition with a gradual, sustained routine

Lemme Burn Capsules may be a good fit if you:

  • Are comfortable with capsules and want a more focused metabolic intervention

  • Are pairing supplementation with an active fitness or lifestyle routine

  • Want the AMPK-targeted mechanism specifically

  • Prefer a sugar-free format (the Capsules contain no added sugar)

That said, choosing one over the other isn't the only option — and some people benefit from both.


 

Some people benefit from both

A common question we get: "Can I take Lemme Burn Gummies and Lemme Burn Capsules together?"

The honest answer: yes, some Lemme customers incorporate both into their daily routine — and there's a scientific rationale for why that can make sense.

The two formulas are built around different lead actives. Morosil® is exclusive to the Gummies. Actiponin® and the high-potency green tea extract are exclusive to the Capsules. Both formulas do contain B6 and B12 as supportive ingredients — but the combined doses, even when stacked, remain well within established safe intake levels for these water-soluble vitamins (see the FAQ below for the full breakdown).

The mechanisms are genuinely complementary. Lipid metabolism (the Morosil® pathway) and AMPK activation (the Actiponin® and EGCG pathway) are two distinct ways the body manages energy. Some people choose to support both.

Format and timing flexibility. Some users take the Capsules in the morning with food (per label) and the Gummies as part of their daily routine. Others alternate based on lifestyle or preference. There's no rigid stacking protocol — it's a personal choice based on individual goals and routine.

That said, we'd never make a blanket recommendation. Stacking decisions should always involve your healthcare provider — particularly if you're on medications, pregnant or nursing, or have an underlying medical condition. The label on each Lemme Burn product directs consumers to consult a physician before use; that direction applies double when stacking.

"For consumers considering both products, the most important thing is that the formulations don't share active ingredients — so you're not over-consuming any single compound. But individual physiology, lifestyle, and goals vary, and any stacking decision should be made in partnership with a healthcare provider who knows your full health context." Dr. Valenton, MD


Frequently asked questions

Are Lemme Burn Gummies and Capsules the same product?

No. They're two distinct formulations within the Lemme Burn franchise. The Gummies feature Morosil® for body composition support; the Capsules feature Actiponin® and high-potency green tea extract for AMPK activation. The two products don't share active ingredients.

Can I take Lemme Burn Gummies and Capsules together?

Some Lemme customers do, because the two formulas are built around different lead actives. However, stacking decisions should always involve your healthcare provider — especially if you're on medications, pregnant or nursing, or have an underlying medical condition.

What about the B vitamins — am I taking too much if I stack both products?

Both Lemme Burn formulas include Vitamin B6 and B12 to support normal metabolism.* Combined, two Gummies and two Capsules deliver 8mg of B6 and 525mcg of B12 daily. B6 and B12 are both water-soluble vitamins, meaning the body generally excretes excess amounts rather than storing them. The combined doses remain well within established safe intake levels: the NIH Tolerable Upper Intake Level for B6 in adults is 100mg/day, and B12 has no established upper limit due to its low toxicity profile. That said, if you're already supplementing with B vitamins separately or have a medical condition affecting nutrient metabolism, consult your healthcare provider before stacking.

Which is more potent — Gummies or Capsules?

Both products deliver their lead active at the dose used in clinical research — 400mg of Morosil® in two Gummies, 450mg of Actiponin® in two Capsules. "Potency" depends on which mechanism you're looking at: the Gummies target lipid metabolism, the Capsules target AMPK activation.

Do they have the same B vitamin content?

No. The Gummies contain 3mg B6 and 25mcg B12. The Capsules contain 5mg B6 and 500mcg B12 — a higher dose. Both products deliver B12 in its bioactive form (methylcobalamin).

Does either contain caffeine?

The Gummies contain no caffeine. The Capsules contain a trace amount of caffeine, naturally present in the green tea extract. Caffeine-sensitive individuals should be aware.

How long does each take to work?

Clinical research on both lead actives observed measurable changes over 12 weeks of consistent daily use. Committing to at least 90 days is recommended for a fair evaluation of either product.

Are both vegetarian and gluten-free?

Yes. The Gummies are vegetarian (gelatin-free) and gluten-free. The Capsules are vegetarian and gluten-free. Both are made without synthetic dyes.

Can either be taken while pregnant or breastfeeding?

No. Per the product labels: if you are pregnant, nursing, have a medical condition, or are taking any medication, consult your physician before use of either product.


 


 

Sources & references

  1. Cardile V, Graziano ACE, Venditti A. (2015). Clinical evaluation of Moro (Citrus sinensis (L.) Osbeck) orange juice supplementation for the weight management. Natural Product Research. PubMed: 25588369

  2. Briskey D, Malfa GA, Rao A. (2022). Effectiveness of "Moro" Blood Orange Citrus sinensis Osbeck (Rutaceae) Standardized Extract on Weight Loss in Overweight but Otherwise Healthy Men and Women — A Randomized Double-Blind Placebo-Controlled Study. Nutrients. PMC8838101

  3. Titta L, Trinei M, Stendardo M, et al. (2010). Blood orange juice inhibits fat accumulation in mice. International Journal of Obesity. PubMed: 19738534

  4. Park SH, Huh TL, Kim SY, et al. (2014). Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): A randomized, double-blind, placebo-controlled trial. Obesity. Wiley

  5. Gauhar R, Hwang SL, Jeong SS, et al. (2012). Heat-processed Gynostemma pentaphyllum extract improves obesity in ob/ob mice by activating AMP-activated protein kinase. Biotechnology Letters. PubMed: 22576281

  6. Hardie DG, Ross FA, Hawley SA. (2012). AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nature Reviews Molecular Cell Biology. Nature

  7. Yang CS, Zhang J, Zhang L, Huang J, Wang Y. (2016). Mechanisms of body weight reduction and metabolic syndrome alleviation by tea. Molecular Nutrition & Food Research. PMC4991829

  8. National Institutes of Health, Office of Dietary Supplements. Vitamin B6 — Health Professional Fact Sheet. Link

  9. National Institutes of Health, Office of Dietary Supplements. Vitamin B12 — Health Professional Fact Sheet. Link

 


 

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This article is for informational purposes only and is not intended as medical advice. Consult your healthcare provider before starting any new supplement, especially if you are pregnant, nursing, have a medical condition, or are taking medications.

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